April 11-12, 2007. AlphaSniffer presents a pre-production novel highly-sensitive biodetector at the SPIE Defense and Security Symposium in Orlando, Fla. Visit booth # 1450 for a demonstration.

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AlphaSniffer will demonstrate its prototype label-free multiplexed biodetector on April 11 and 12 at the SPIE Defense and Security Symposium in Orlando, Fla. in booth #1450. For more information visit the exhibitor detail at the SPIE web site.

At 9AM in Grand 5-6 room on April 12 AlphaSniffer's Senior Biochemist Dr Greef presents a report entitled

Rapid, multiplexed, high-sensitivity detection of biowarfare agents by surface plasmon resonance enhanced common path interferometry

Charles Greef, Viatcheslav Petrapavlovskikh, Oyvind Nilsen, Bilge Hacioglu, AlphaSniffer, LLC; John Hall, Hall Stable Lasers, LLC

Real time monitoring of biowarfare agents for military and civilian protection remains a high priority for homeland security and battlefield readiness. Available devices have sensitivity adequate for BWA detection, but the detection modules have limited periods of deployment, require frequent maintenance, employ single-use disposable components, and have limited multiplexing capability. Surface Plasmon Resonance(SPR) Common Path Interferometry (CPI) is a label-free, high sensitivity biomolecule interaction measurement technology that allows multiplexed real-time measurement of biowarfare agents, including small molecules, proteins, and microbes. The technology permits continuous operation in a field deployable detection module of an integrated BWA monitoring system. SPR-CPI measures differences in phase shift of reflected S and P polarized light (under TIR conditions) at a surface, caused by changes in refractive index induced by biomolecular interactions within the evanescent field at the TIR interface. The measurement is performed on a discrete 2-dimensional area functionalized with biomolecule capture reagents in a microarray format, allowing simultaneous measurement of up to 100 separate analytes. Since the optical beam spans the entire area of the transducer array, optical scanning is not required, enabling a highly robust BWA monitoring solution. Output consists of simultaneous voltage measurements proportional to the phase differences resulting from the refractive index changes, is automatically processed and displayed graphically or delivered to a decision making algorithm, enabling a fully automatic field-deployable detection system capable of integration into existing modular BWA detection systems. Proof-of-concept experiments on surrogate models of anticipated BWA threats have demonstrated utility, and efforts are in progress for full development and deployment of the device.

Download a copy of the presentation in PDF format or Flash format.