May 16, 2007. AlphaSniffer presents a poster describing it's novel biodetector at the innagural Lab-On-a-Chip World Congress.

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AlphaSniffer's Senior Scientist Dr Chad Greef presented a poster at the Lab-On-a-Chip World Congress, an inaugural conference designed to review existing and new life science applications of microfluidic technologies. For more information about the conference visit its website. You can read the abstract of the presentation below or download the enrire poster in PDF format.

Abstract
Surface Plasmon Resonance enhanced Common Path Interferometry (SPR-CPI) is a high sensitivity label free microarray detection technology based on simultaneous phase differential measurement of separate aspects in a single laser beam (1,2). The phase differential response is enhanced by applying the surface plasmon resonance effect. Two dimensional cross sections of the beam are parsed into discreet analysis areas and measured by an aligned photo diode array, enabling multiple analyses in a microarray format. Microarrays of biomolecular capture reagents are printed in the biosensor region, and assayed for binding interactions with analyte targets. The binding interactions cause refractive index changes at the surface, resulting in differential phase changes which are measured as the CPI signal. The technology has been incorporated into an integrated biosensor system that is robust, compact and easy to use. Proof of concept studies using nucleic acids, proteins, and bacterial cultures have demonstrated utility. Future studies will focus on technical refinements and applications in drug discovery research, environmental monitoring, and diagnostics. The combination of common path interferometry with SPR for biosensor applications is unprecedented and is a significant technical advancement of label free detection technologies.

Download a copy of the presentation in PDF format.